- Assistant Professor of Ophthalmic Science (in Ophthalmology)
Research in Dr. Nagasaki’s laboratory is aimed toward understanding the biology of an anterior segment at a molecular and cellular level for better management of injuries and diseases of the cornea and the conjunctiva.
Currently Dr. Nagasaki’s main focus is on the ocular surface stem cells - epithelial stem cells of the cornea and the conjunctiva - that play a central role in maintenance of normal epithelium as well as a repair of damaged epithelium. He is asking questions about the distribution, movement, turnover, and differentiation of epithelial stem cells, using modern cell biological techniques including in vivo time-lapse fluorescence microscopy, hyperspectral imaging, and computer-assisted modeling.
His laboratory is also investigating how the normal cornea maintains avascularity and what triggers blood vessel growth in the cornea - potentially blinding condition, using mutant mice that are predisposed for spontaneous vascularization in the cornea.
Dr. Nagasaki's research page
Jin Zhao, M.D., Ph.D. Associate Research Scientist
Edward S. Harkness Eye Institute Research Annex160 Fort Washington Avenue
5th Floor, Room 503
New York, NY 10032
- (212) 305-4654
- (212) 305-7153
- Biology and diseases of an anterior segment of an eye including cornea, conjunctiva, and tears.
- Tosi J, Wang NK, Zhao J, Chou CL, Kasanuki JM, Tsang SH, and Nagasaki T (2010) Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma. Mol Imaging Biol. in press.
- Zhao J, Mo V, and Nagasaki T (2009) Distribution of label-retaining cells in the limbal epithelium of a mouse eye. J. Histochem. Cytochem. 57:177-185, PMC2628319.
- Zhang W, Zhao J, Chen L, Urbanowicz MM, and Nagasaki T (2008) Abnormal epithelial homeostasis in the cornea of mice with destrin deletion. Mol. Vis., 14:1929-1939.