Our Providers

Takayuki Nagasaki, PhD
  • Assistant Professor of Ophthalmic Science (in Ophthalmology)
Takayuki Nagasaki, <span>PhD</span>

Research in Dr. Nagasaki’s laboratory is aimed toward understanding the biology of an anterior segment at a molecular and cellular level for better management of injuries and diseases of the cornea and the conjunctiva.

Currently Dr. Nagasaki’s main focus is on the ocular surface stem cells - epithelial stem cells of the cornea and the conjunctiva - that play a central role in maintenance of normal epithelium as well as a repair of damaged epithelium. He is asking questions about the distribution, movement, turnover, and differentiation of epithelial stem cells, using modern cell biological techniques including in vivo time-lapse fluorescence microscopy, hyperspectral imaging, and computer-assisted modeling.

His laboratory is also investigating how the normal cornea maintains avascularity and what triggers blood vessel growth in the cornea - potentially blinding condition, using mutant mice that are predisposed for spontaneous vascularization in the cornea.
Dr. Nagasaki's research page

Staff
Jin Zhao, M.D., Ph.D. Associate Research Scientist

Lab Locations

  • Edward S. Harkness Eye Institute Research Annex

    160 Fort Washington Avenue
    5th Floor, Room 503
    New York, NY 10032
    Phone:
    (212) 305-4654
    Fax:
    (212) 305-7153
    Email:
    tn4@columbia.edu

Research Interests

  • Biology and diseases of an anterior segment of an eye including cornea, conjunctiva, and tears.

Publications

  • Tosi J, Wang NK, Zhao J, Chou CL, Kasanuki JM, Tsang SH, and Nagasaki T (2010) Rapid and noninvasive imaging of retinal ganglion cells in live mouse models of glaucoma. Mol Imaging Biol. in press.
  • Zhao J, Mo V, and Nagasaki T (2009) Distribution of label-retaining cells in the limbal epithelium of a mouse eye. J. Histochem. Cytochem. 57:177-185, PMC2628319.
  • Zhang W, Zhao J, Chen L, Urbanowicz MM, and Nagasaki T (2008) Abnormal epithelial homeostasis in the cornea of mice with destrin deletion. Mol. Vis., 14:1929-1939.